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Creative Biostructure is highly-experienced in custom mutagenesis libraries construction services for directed evolution. Site-saturation mutagenesis (SSM) can generate random or targeted mutations and screen the library of protein variants for functional alterations. Notably, our protein evolution and engineering platform holds many advantages for custom SSM libraries services, including extremely cost-efficient, fast delivery time, fewer variants to screen and, systematic identification of beneficial amino acid substitutions.
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Continuous evolution methods are developed recently to overcome some disadvantages of traditional protein evolution methods such as the requirements for discrete time- and labor- intensive steps during the construction and introduction of gene libraries, screening and selections, isolation of gene library members, etc. In continuous evolution methods, every steps of a protein evolution cycle can be performed continuously with no need for manual intervention. Most of the continuous evolution experiments have selected for replicative fitness of hosts under a continuous dilution, and have been ap
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plied for various evolution targets such as bacteria genomes for faster replication speed and resistance to antibiotics. The continuous evolution methods significantly improve the efficiency of protein evolution assays, along with the number of steps in the sequence space that can be explored in the screening for desired optimal protein variants.
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Using immuno-electron microscopy, Creative Biostructure can localize molecules at the ultrastructural level by labeling them with specific antibodies.
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Creative Biostructure provides de novo design related services to clients for protein engineering.
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The Plasmid Design and Construction platform developed by Creative Biostructure is aimed to rapidly and reliably deliver application-specialized plasmids. We are specialized in the construction of custom plasmids, starting from initial design strategy to the plasmids construction process. Before you start any project, Creative Biostructure also provides protein domain prediction services based on bioinformatics and biochemical analysis.
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Creative Biostructure deliver application-specialized plasmids design and construction services include vector construction, gene delivery, and plasmid production,
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Creative Biostructure has established an innovative Mempro™ Liposome platform to provide novel functional liposomes including Mempro™ Proteoliposomes
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Structural biology incorporates techniques and principles of molecular biology, biochemistry and biophysics as a means of elucidating the molecular structure and dynamics of biologically relevant molecules. Recent progress in instrumentation has endorsed a new boost in structural biology as complex biological molecules can now be analyzed with unprecedented ease and efficiency. The three-dimensional structure of proteins and protein complexes provide great insights into the laws of life activities and mechanism of diseases, and thereby allowing rational design of novel diagnostic and therapeut
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ic agents. There are three main research techniques for structural biology: single crystal X-ray diffraction (SC-XRD), nuclear magnetic resonance (NMR) and cryo-electron microscopy (Cryo-EM). However, there is no “all-purpose” method since all three of them offer unique advantages as well as limitations.